viernes, 13 de agosto de 2010

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Proc Natl Acad Sci U S A. 2010 January 19; 107(3): 1207–1210.
Published online 2009 December 28. doi: 10.1073/pnas.0911268107.
PMCID: PMC2824261

Autores: Hidehiko Okamoto,a1 Henning Stracke,a1 Wolfgang Stoll,b2 and Christo Panteva3

Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus patients to self-chosen, enjoyable music, which was modified (“notched”) to contain no energy in the frequency range surrounding the individual tinnitus frequency. After 12 months of regular listening, the target patient group (n = 8) showed significantly reduced subjective tinnitus loudness and concomitantly exhibited reduced evoked activity in auditory cortex areas corresponding to the tinnitus frequency compared to patients who had received an analogous placebo notched music treatment (n = 8). These findings indicate that tinnitus loudness can be significantly diminished by an enjoyable, low-cost, custom-tailored notched music treatment, potentially via reversing maladaptive auditory cortex reorganization.
Keywords: cortical plasticity, human auditory cortex, lateral inhibition , magnetoencephalography, MEG
Subjective tinnitus (1) is among the most prevalent symptoms of hearing disorders in industrialized countries (2, 3). Tinnitus loudness can be considered as the most tangible tinnitus characteristic. In 1–3% of the general population, the tinnitus sensation is loud enough to affect the quality of life (4). Causal treatment strategies for tinnitus are not yet available.
The lack of treatment strategies is due to incomplete knowledge concerning the mechanisms of tinnitus generation and maintenance. However, recent neurophysiological studies have shown that tinnitus is presumably caused by maladaptive auditory cortex reorganization (46) (similar phenomena were observed also in somatosensory cortex; refs. 79). For instance, magnetoencephalography (MEG) studies have demonstrated that auditory cortical map areas corresponding to the tinnitus frequency were distorted; the amount of distortion correlated positively with perceived tinnitus strength (10). Moreover, auditory cortex activity corresponding to the tinnitus frequency was shown to be enhanced and related to perceived tinnitus intrusiveness (11).
To date, widely used tinnitus treatment strategies (e.g., tinnitus retraining therapy; ref. 12) are merely symptom management approaches. Therefore, there is a great demand for causal treatment approaches targeting the tinnitus percept more directly. Recent neurophysiological studies indicate that behavioral training can be a powerful means to reverse maladaptive cortical reorganization (7, 13).
A previous study (14) demonstrated that listening to spectrally “notched” music can reduce cortical activity corresponding to the notch center frequency, possibly through lateral inhibition. Motivated by this finding, we developed an innovative tinnitus treatment strategy aimed at reducing tinnitus loudness. The treatment regimen consists of regular listening to enjoyable, custom-tailored notched music. Here, we evaluate and report results of the treatment from a longitudinal double-blinded study. Three groups of patients suffering from chronic, tonal tinnitus participated in the study: (i) target notched music treatment (n = 8; Fig. 1 and Movie S1), (ii) placebo notched music treatment (n = 8; Fig. 2 and Movie S2), and (iii) monitoring (n = 7; no treatment). Treatment outcomes were evaluated using both subjective and neurophysiological measurements.

Fig. 1.
Fig. 1.
Target treatment. A frequency band of one octave width centered at the individual tinnitus frequency was removed from the music energy spectrum via digital notch filter. Exemplary music (MP3 format) is available as Movie S1.

Fig. 2.
Fig. 2.
Placebo treatment. A moving notch filter (dotted arrow) of one octave width was applied to the music energy spectrum. The energy in the frequency band ranging from 0 to 707 Hz and the energy in the 1-octave frequency band surrounding the individual tinnitus (more ...)

The patients who received the music treatment were assigned to the target or placebo group pseudorandomly. The monitoring group consisted of patients who were not able to perform the music training because of lack of time (i.e., these patients were not randomly assigned to this group). On average (mean ± SD), the three groups did not differ significantly in age (40.5 ± 10.8 years; range 18–55 years) or the tinnitus characteristics (i) duration (5.3 ± 5.6 years; range 1.2–24.8 years), (ii) frequency (5,949 ± 1,886 Hz; range 2,375–8,000 Hz), (iii) tinnitus-related distress (15) (18.4 ± 10.8; range 1–38; scale 0–84), and (iv) loudness (49.7 ± 16.9; range 10–78; scale 0–100). Baseline N1m auditory evoked response ratios (16), as well as auditory steady state response (ASSR) (17) ratios as measured by MEG did not differ significantly between groups. Furthermore, retrospective analysis revealed that the target and placebo groups did not differ significantly on measures of average music listening times (12.4 ± 3.5 h per week; range 7–21 h per week) and subjective music enjoyment (67.6 ± 26.9; range 13–100; scale 0–100).
Figs. 3 and and44 demonstrate the results of tinnitus loudness, ASSR, and N1m measurements for all groups. In the target group, tinnitus loudness was significantly reduced after 12 months of treatment compared to baseline (F(1,7) = 26.1, P = 0.001). Moreover, there was a significant interaction between group (target vs. placebo) and time point of measurement [baseline vs. average across months 7–12 (F(1,14) = 5.9, P = 0.030)]. In contrast, for the placebo and monitoring groups significant differences from baseline were not found, indicating that a systematic change in tinnitus loudness was not present in these groups.

Fig. 3.
Fig. 3.
Normalized tinnitus loudness change after 6 and 12 months of treatment (or monitoring) relative to baseline (0) for the three patient groups (target, placebo, and monitoring). Positive change values reflect impairment, negative change values reflect improvement. (more ...)

Fig. 4.
Fig. 4.
Normalized tinnitus-related auditory cortex evoked activity change after 6 and 12 months of treatment (or monitoring) relative to baseline (0) for the three patient groups (target, placebo, and monitoring). Positive change values reflect increment, negative (more ...)
In the target group, both ASSR source strength ratios (representing primary auditory cortex evoked activity; ref. 18) and N1m source strength ratios (representing mainly belt auditory cortex evoked activity; ref. 18) were significantly reduced after 12 months of treatment (ASSR: F(1,7) = 5.9, P = 0.045; N1m: F(1,7) = 24.6, P = 0.002). Again, there was a significant interaction between group (target vs. placebo) and time point of measurement (baseline vs. month 12) for both ASSR (F(1,14) = 6.1; P = 0.027) and N1m (F(1,14) = 13.1; P = 0.003). In contrast, for the placebo and monitoring groups no significant differences from baseline were observed in the ASSR or N1m.
All reduction effects observed in the target group (Figs. 3 and and4)4) were statistically significant already after 6 months of treatment (loudness: F(1,9) = 8.1, P = 0.019; ASSR: F(1,9) = 11.2, P = 0.007; N1m: F(1,9) = 13.2, P = 0.005). Crucially, the correlation between tinnitus loudness change and auditory evoked response ratio change was highly significant for the ASSR (r = 0.69, P = 0.003) but not significant for the N1m (r = 0.17, P = 0.53) after 12 months of treatment. The significant positive correlation indicates a strong correspondence between changes in tinnitus loudness (improvement vs. impairment) and reorganization of neural activity in primary auditory cortex (decrement vs. increment) over time.

In the target group we observed significant reductions in both tinnitus loudness and tinnitus-related auditory cortex evoked activity relative to baseline. Crucially, such significant changes were not observed in the placebo or monitoring groups. Moreover, the changes in loudness as well as tinnitus-related auditory cortex evoked activity were significantly different between target and placebo groups. Considering these findings, and taking into account a large epidemiological study (19) demonstrating that there is no general tinnitus loudness reduction trend over time, our findings strongly imply that the improvement in the target group reflects a specific treatment effect of custom-tailored target modification of the music.
It has been clearly demonstrated that tinnitus is generated in the central auditory system, possibly due to maladaptive cortical reorganization (36, 20). For instance, auditory cortex neurons that are deprived of normal thalamo-cortical input due to hearing loss do not become inactive, but “rewire” with excitatory inputs from neighboring neurons (21, 22). As a result of bottom-up input deprivation, the neurons are no longer excitable by the frequencies they were originally tuned to, but become sensitive to neighboring frequencies because of the rewiring. In this scenario tonotopic maps can literally, and maladaptively “fuse” (20, 23). Crucially, such fused cortical areas would be characterized by less lateral inhibitory networks (24) and may generate tinnitus by means of synchronized spontaneous neural activity (25). Such pathological spontaneous activity synchronization evidently interacts with other brain regions (26), and has been shown to be closely related to tinnitus loudness (27, 28) and tinnitus duration (29).
Despite the existence of diseases caused by maladaptive cortical reorganization, the consequences of reorganization can be beneficial (7, 30). Here, we used knowledge regarding maladaptive cortical reorganization in tinnitus to design a procedure that appears suited to reduce brain activity corresponding to the tinnitus frequency and thus possibly tinnitus perception. Our target notched music introduced a functional deafferentation of auditory neurons corresponding to the eliminated frequency band, and because this frequency band overlapped the individual tinnitus frequency, the notched music no longer stimulated the cortical area corresponding to the tinnitus frequency, although it still excited surrounding neurons. Thus, the neurons, which were not stimulated due to the notch, were presumably actively suppressed via lateral inhibitory inputs originating from surrounding neurons (14, 31, 32). Alternatively, listening to the target notched music could have induced synaptic and/or cellular plasticity mechanisms (33, 34). For instance, the deprivation from auditory input in the frequency range of the tinnitus frequency could have caused long-term depression of auditory neurons corresponding to the tinnitus frequency.
One might presume that listening to a band-eliminated broadband stimulus like notched music may cause a phantom auditory sensation, the so-called Zwicker tone (35). However, our additional behavioral study (described in SI Text) demonstrated that notched music could not elicit a Zwicker tone, whereas notched broadband noise could. These results support the hypothesis that noise detecting neurons would play an important role in generating the Zwicker tone (36).
The described reversion of maladaptive cortical reorganization by the notched music training would have been initiated by bottom-up neural inputs triggered by the music. However, top-down neural processes also play an essential role in cortical reorganization (37). In the present study, patients were given the opportunity to listen to their most enjoyable music. It is reasonable to assume that enjoyable music strongly engages attention, and evidently it affects brain functioning (38). As such, joyful listening to music activates the reward system of the brain (39) and leads to release of dopamine, which plays an important role in cortical reorganization (40). Thus, a combination of bottom-up and top-down neural processes initiated by the target notched and relished music could provide a basis for the reversion of the putative maladaptive cortical reorganization underlying tinnitus emergence and maintenance in auditory cortex.
Evoked cortical source strength measured by MEG represents the quantity as well as the synchronicity of activated cortical neurons. Therefore, the present MEG results strongly suggest that the number of active neurons and/or the synchrony of these neurons, which correspond to a cortical area that contributes to the tinnitus perception, cumulatively decreased after regular listening to appreciated, target notched music. The decrement of this population-level neural activity likely reflects reduction of pathological auditory neural activity corresponding to the tinnitus frequency and consequently may have resulted in reduced tinnitus loudness.
It is important to note that this interpretation is supported by the correlation between tinnitus loudness change and 40-Hz ASSR ratio change. Given that tinnitus perception arises in auditory cortex, it is possible that the ASSR decrement, which could have resulted from the target notched music induced cortical reorganization, might have resulted in reduced tinnitus loudness. A previous study (28) demonstrated that gamma band (30–45 Hz) oscillations in auditory cortex reflected subjective tinnitus loudness as measured by visual analog scale. This finding might explain why in the present study the 40-Hz ASSR change correlates more strongly with the tinnitus loudness change than does the N1m response change.
In conclusion, our tailor-made notched music treatment strategy is derived from recent neuroscientific findings and targets the reversion of the maladaptive reorganization of a specific cortical area contributing to the perception of tinnitus. The notched music approach can be considered as enjoyable, low cost, and presumably causal treatment that is capable of specifically reducing tinnitus loudness. The notched music training could significantly complement widely used and rather indirect psychological treatment strategies for altering distributed cortical networks (12).

Llegan las e-drugs

  • Se trata de un fenómeno neurológico, las e-drugs se fundamentan en los latidos binaturales, este fenómeno consiste en emitir sonidos distintos en cada oído y que estimula el cerebro, produciendo sensaciones de euforia, estados de trance o de relajación.
Eso según las personas que las consumen, es suficiente una dosis de 15 a 30 minutos de zumbidos,  tales sonidos son accesibles para todo público en portales especializados.
Los precios de este suceso oscilan entre los 7 y los 150 euros y que transportan a los usuarios a unas sensaciones fuera de lo común.
Claro que este tipo de droga no tiene nada que ver con una persona que escuche música desde su reproductor, más bien dista de las sustancias que se engloban bajo el título de los estupefacientes.
Productos que nacieron en Estados Unidos, pero su éxito y las nuevas tecnologías han extendido su uso rápidamente por el resto del mundo, algo que ha despertado reticencias en ciertos sectores, pese a que no crean adicción alguna, dicen los expertos.
Algunas instituciones opinan que no es una amenaza,  se trata de un fenómeno que no es “ni inquietante, ni emergente” y que, por el momento, no hay razón para prohibirlo.
Aún así estas drogas digitales han irrumpido en este país en los últimos dos meses y por ahora se desconoce qué tipo de efectos pueden acarrear a los consumidores.
Expertos en neuropsicología remarcan que los latidos binaurales relajan, ayudan a la concentración y se usan con fines terapéuticos para enfermedades como el autismo.