domingo, 17 de noviembre de 2013

Counteracting tinnitus by acoustic coordinated reset neuromodulation

Counteracting tinnitus by acoustic
coordinated reset neuromodulation
Peter A. Tass
, Ilya Adamchic
, Hans-Joachim Freund
, Tatjana von Stackelberg
and Christian Hauptmann
Research Center J ̈
ulich, Institute for Neuroscience and Medicine – Neuromodulation INM-7, J ̈
ulich, Germany
Department of Stereotaxic and Functional Neurosurgery, University Hospital, Cologne, Germany
Ear, Nose and Throat (ENT) Center, Meerbusch, Germany

Purpose: Subjective tinnitus is associated with pathologic enhanced neuronal synchronization. We used a model based desynchronization technique, acoustic coordinated reset (CR) neuromodulation, to specifically counteract tinnitus-related
neuronal synchrony thereby inducing an unlearning of pathological synaptic connectivity and neuronal synchrony.
Methods: In a prospective, randomized, single blind, placebo-controlled trial in 63 patients with chronic tonal tinnitus and up
to 50 dB hearing loss we studied safety and efficacy of different doses of acoustic CR neuromodulation. We measured visual
analogue scale and tinnitus questionnaire (TQ) scores and spontaneous EEG.
Results: CR treatment was safe, well-tolerated and caused a significant decrease of tinnitus loudness and symptoms. 
Placebotreatment did not lead to any significant changes. 
Effects gained in 12 weeks of treatment persisted through a preplanned 4-weektherapy pause and showed sustained long-term effects after 10 months of therapy: Response, i.e. a reduction of at least 6 TQpoints, was obtained in 75% of patients with a mean TQ reduction of 50% among responders. CR therapy significantly loweredtinnitus frequency and reversed the tinnitus related EEG alterations.
Conclusion: The CR-induced reduction of tinnitus and underlying neuronal characteristics indicates a new non-invasive therapy
which might also be applicable to other conditions with neuronal hypersynchrony.

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