jueves, 30 de diciembre de 2010

ACUFENOS-Seccíon Tipos de Acúfenos

Pulsatile tinnitus
as a first symptom of essential thrombocythemia

Haruka Okazaki MD1, a, Tadashi Doi MDCorresponding Author Contact Information, 1, a, E-mail The Corresponding Author, Masahiko Izumikawa MDa, Naoko Kaneda MDa, Hisashi Ooka MDa, Hideto Fukui MDa and Koichi Tomoda MDa

a Department of Otolaryngology, Kansai Medical University, Hirakata, Osaka, Japan
Received 23 February previous term2010.next term 
Available online 30 April previous term2010.next term


previous termTinnitusnext term is the sensation of sound inside the head and is a common symptom encountered daily by otorhinolaryngologists.
Pulsatile previous termtinnitusnext term sufferers hear rhythmical noise at the same rate as a heartbeat and can present a diagnostic challenge. In this report, we present a 32-year-old patient with pulsatile previous termtinnitusnext term that led to the diagnosis of essential thrombocythemia.
The symptom of pulsatile previous termtinnitusnext term allowed an early diagnosis of essential thrombocythemia and a more favorable prognosis.
The case demonstrates the importance of blood tests for all patients who present with pulsatile previous termtinnitusnext term of unknown origin.


By Mayo Clinic staff Essential thrombocythemia (ET) is an uncommon disorder in which your body produces too many blood platelets (thrombocytes). It's also known as primary thrombocythemia (throm-bo-sigh-THE-me-uh). Essential thrombocythemia is one of a group of diseases of the blood and bone marrow known as myeloproliferative neoplasms.
The most common symptoms of essential thrombocythemia include headache, lightheadedness, vision changes, and tingling, numbness or burning pain in the hands and feet. Essential thrombocythemia most often occurs in people over age 50 and is more common in women.
You may not need treatment for essential thrombocythemia if you're not experiencing symptoms. If you have abnormal blood clotting or bleeding, however, medications can help you avoid potentially serious complications.
Many people with essential thrombocythemia have no signs or symptoms. The first indication you have the disorder may be the development of a blood clot (thrombus). Although clots can develop anywhere in your body, with ET, they occur most often in your brain, hands and feet.
Signs and symptoms depend on where the clot forms. They include:
  • Headache
  • Dizziness or lightheadedness
  • Chest pain
  • Weakness
  • Fainting
  • Temporary vision changes
  • Numbness or tingling of the hands and feet
  • Redness, throbbing and burning pain in the hands and feet (erythromelalgia)
  • Mildly enlarged spleen
Less commonly, ET may cause bleeding, especially if your platelet count is extremely high (more than 1 million platelets per microliter of blood). Bleeding may take the form of:
  • Nosebleeds
  • Bruising
  • Bleeding from your mouth or gums
  • Bloody stool
A blood clot may cause a transient ischemic attack (TIA) — a temporary interruption of blood flow to part of the brain — or stroke. Signs and symptoms develop suddenly and include:
  • Weakness or numbness of your face, arm or leg, usually on one side of your body
  • Difficulty speaking or understanding speech (aphasia)
  • Blurred, double or decreased vision
When to see a doctor
If you have any signs or symptoms of abnormal blood clotting or bleeding, see your doctor.
If you develop signs or symptoms of a TIA or stroke, such as numbness or paralysis on one side of your body, seek medical attention immediately.


By Mayo Clinic staff Bone marrow — spongy tissue inside your bones — contains stem cells that can become red blood cells, white blood cells or platelets. Platelets travel through your blood vessels. They stick together to form clots that stop the bleeding when you damage a blood vessel, such as when you get a cut. A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood.
If you have essential thrombocythemia, your bone marrow makes too many platelet-forming cells (megakaryocytes), which release too many platelets into your blood. The excess platelets may not function normally, leading to abnormal clotting or bleeding.
The exact cause of ET and other myeloproliferative neoplasms isn't known. About half the people with the disorder have a mutation of the Janus kinase 2 (JAK2) gene. Other gene mutations also have been associated with ET. The role of these mutations in causing the disease is still being investigated. A rare form of thrombocythemia is inherited.
A high platelet count that's caused by an underlying condition such as an infection or iron deficiency is called reactive or secondary thrombocytosis.


By Mayo Clinic staff The abnormal blood clotting of essential thrombocythemia can lead to a variety of potentially serious complications, including:
  • Pregnancy complications. Uncontrolled thrombocythemia can cause miscarriage, premature delivery, high blood pressure (preeclampsia), early separation of the placenta from the uterine wall (placental abruption) and slow fetal growth. If you have ET and become pregnant, be sure your doctor monitors you carefully throughout your pregnancy.
  • Stroke. A clot that blocks blood flow to your brain can cause a stroke. If you develop signs and symptoms of a stroke, get immediate medical attention.
  • Heart attack. A clot that obstructs blood flow to your heart can cause a heart attack. If you develop signs and symptoms of a heart attack, such as pressure, fullness or a squeezing pain in the center of your chest lasting more than a few minutes; pain extending to your shoulder, arm, back, teeth or jaw; shortness of breath; and sweating or clammy skin, get immediate medical attention.
Essential thrombocythemia can also cause bleeding (hemorrhage) with significant blood loss. A small minority of people with ET may later develop acute leukemia or myelofibrosis, both of which can be life-threatening:
  • Acute leukemia. Acute myelogenous leukemia is a type of blood and bone marrow cancer that progresses rapidly.
  • Myelofibrosis. This progressive bone marrow disorder results in bone marrow scarring, severe anemia, and enlargement of your liver and spleen.
Blood tests that can help confirm a diagnosis of essential thrombocythemia include:
  • Complete blood count (CBC). This test determines the number of platelets in your blood.
  • Blood smear. A small amount of your blood is examined under a microscope to view the condition of your platelets, such as whether they're abnormally large or clumped together.
  • Genetic testing. Special tests can determine whether you have chromosomal abnormalities that can cause a high platelet count and whether you have a JAK2 gene mutation.
  • Other blood tests. Your doctor may check the level of iron in your blood or test for markers of inflammation.
If your blood count is above 450,000 platelets per microliter of blood, your doctor will look for an underlying condition. If there's no evident cause of your high platelet count, and it remains high over time, your doctor may suggest a bone marrow test. The two types of bone marrow tests provide different but complementary information about your blood cells. Often they're done together.
  • Bone marrow aspiration. Your doctor extracts a small amount of your liquid bone marrow through a needle and examines it under a microscope, looking for abnormal cells.
  • Bone marrow biopsy. Your doctor takes a sample of solid bone marrow tissue through a needle for examination under a microscope. If you have ET, your bone marrow has a higher than normal number of the large cells that make platelets (megakaryocytes).

Treatments and drugs

By Mayo Clinic staff Treatment of essential thrombocythemia depends on your risk of blood-clotting or bleeding episodes. If you're younger than 60, have had no signs or symptoms and have no other risk factors for developing blood clots, such as smoking, you may simply need periodic medical checkups. If you're older than 60 and have had previous signs and symptoms of blood clots, your doctor likely will prescribe medication or a medical procedure to lower your platelet count. Your doctor may also recommend treatment if you have cardiovascular risk factors, such as high cholesterol, high blood pressure or diabetes.
If you're at risk of blood clots, your doctor may recommend low-dose aspirin, particularly if you're pregnant. Aspirin makes the platelets less sticky and your blood less likely to form clots. If you take aspirin during pregnancy, stop taking it at least one week before delivery to lower your risk of bleeding complications during delivery.
Drugs that reduce the platelet count and are commonly used to treat ET include:
  • Hydroxyurea (Droxia, Hydrea). This drug suppresses bone marrow production of blood cells, including platelets. Also used to treat cancers, it's the most commonly prescribed platelet-lowering drug for ET. It's often used in combination with low-dose aspirin. If you take hydroxyurea, your doctor will monitor your blood counts closely. There's some concern that long-term use may increase the risk of developing acute myelogenous leukemia.
  • Anagrelide (Agrylin). Unlike hydroxyurea, anagrelide isn't associated with an increased risk of leukemia. But it's not considered as effective as hydroxyurea. Side effects may include fluid retention, heart problems, headaches, dizziness, nausea and diarrhea.
  • Interferon alfa-2B (Intron A). Given by injection, this drug is less convenient to administer than hydroxyurea or anagrelide, may be more expensive and may cause less tolerable side effects. Side effects may include flu-like symptoms, confusion, nausea, depression, diarrhea, seizures, irritability and sleepiness.
Used only in emergencies, such as after a stroke or other dangerous blood clotting, a medical procedure known as plateletpheresis can be used to rapidly lower platelet count. During the procedure, an intravenous (IV) needle connected to a tube is inserted into one of your blood vessels. Your blood flows through the tube and into a device that removes platelets from your blood. The remaining portion of your blood (plasma) and your red cells are then returned to you through an IV line. The effect is temporary.

Corresponding Author Contact InformationCorresponding author. Department of Otolaryngology, Kansai Medical University, Shin-machi 2-3-1, Hirakata, Osaka 573-1191, Japan. Tel.: +81 72 804 0101; fax: +81 72 804 2069.
1 First 2 authors contributed equally to this paper.

Fuente de la infomacion clinica : Clinica Mayo 

2 comentarios:

  1. Muy interesante! Soy músico, entré buscando un tratado que escribió Almafuerte sobre Acúfenos, quizás me puedas ayudar. Un abrazo, adelante con tu tarea.

  2. Estimado José, No conozco el libro de almafuerte que mencionás,voy a investigar el tema,

    Almafuerte sí escribio un poema ¡PIU AVANTI!, en el que parece hablar de hiperacusia, en la frase "la cobarde estupidez del pavo, que amaina su plumaje al primer ruido".

    No te des por vencido, ni aun vencido,
    no te sientas esclavo, ni aun esclavo;
    trémulo de pavor, piénsate bravo,
    y arremete feroz, ya mal herido.
    Ten el tesón del clavo enmohecido
    que ya viejo y ruin, vuelve a ser clavo;
    no la cobarde estupidez del pavo
    que amaina su plumaje al primer ruido.
    Procede como Dios que nunca llora;
    o como Lucifer, que nunca reza;
    o como el robledal, cuya grandeza
    necesita del agua y no la implora...
    Que muerda y vocifere vengadora,
    ya rodando en el polvo, tu cabeza!

    Un abrazo
    Dario roitman