Effects of acute thyroxin depletion on hearing in humans†
1. Zan Mra MD1,
2. Mark K. Wax MD2,*
Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences Center, Portland, Oregon
State University of New York at Buffalo, Buffalo, New York, and the Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences Center, Portland, Oregon
*Correspondence: Mark K. Wax MD, Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences University, 3181 Sam Jackson Park Road, Portland, Oregon 97201–3011, U.S.A.
Presented at the Meeting of the Southern Section of the American Laryngological, Rhinological and Otological Society, Inc., New Orleans, Louisiana, January 16, 1999.
Fuente de la imagen: http://www.umm.edu/graphics/images/es/14058.jpg
Objective: To study the physiologic effect of acute thyroid hormone depletion on hearing and the function of outer hair cells.
Design: Audiologic and otoacoustic emission testing of subjects undergoing total thyroidectomy before surgery and up to 6 weeks after surgery. Magnitude of thyroxin depletion monitored by serum thyroid-stimulating hormone levels.
Setting: Hearing research laboratory at a state university. Subjects: Ten patients undergoing total thyroidectomy.
Main Outcome Measures: Detection of hearing loss on audiogram and decrease or disappearance of otoacoustic emissions as a result of acute thyroxin depletion.
Results: No significant changes in the audiogram and otoacoustic emission configurations were detected, although thyroid-stimulating hormone levels became elevated after total thyroidectomy.
Conclusion: Although thyroid hormone is thought to play a role in the physiology of hearing in humans, no deleterious effects on hearing can be identified up to 6 weeks after thyroxin depletion
Fuente: The Laryngoscope, Volume 109, Issue 3, pages 343–350, March 1999
Mra, Z. and Wax, M. K. (1999), Effects of acute thyroxin depletion on hearing in humans. The Laryngoscope, 109: 343–350. doi: 10.1097/00005537-199903000-00001