Audición: Sección fisopatologia: Efectos del agotamiento brusco de Tiroxina sobre la audición humana

Effects of acute thyroxin depletion on hearing in humans†

1. Zan Mra MD1,
2. Mark K. Wax MD2,*

Author Information

1. 1

Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences Center, Portland, Oregon
2. 2

State University of New York at Buffalo, Buffalo, New York, and the Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences Center, Portland, Oregon

*Correspondence: Mark K. Wax MD, Department of Otolaryngology—Head and Neck Surgery, Oregon Health Sciences University, 3181 Sam Jackson Park Road, Portland, Oregon 97201–3011, U.S.A.

1. †

Presented at the Meeting of the Southern Section of the American Laryngological, Rhinological and Otological Society, Inc., New Orleans, Louisiana, January 16, 1999.

Tiroides,
Fuente de la imagen: http://www.umm.edu/graphics/images/es/14058.jpg


Abstract

Objective: To study the physiologic effect of acute thyroid hormone depletion on hearing and the function of outer hair cells.

Design: Audiologic and otoacoustic emission testing of subjects undergoing total thyroidectomy before surgery and up to 6 weeks after surgery. Magnitude of thyroxin depletion monitored by serum thyroid-stimulating hormone levels.

Setting: Hearing research laboratory at a state university. Subjects: Ten patients undergoing total thyroidectomy.

Main Outcome Measures: Detection of hearing loss on audiogram and decrease or disappearance of otoacoustic emissions as a result of acute thyroxin depletion.

Results: No significant changes in the audiogram and otoacoustic emission configurations were detected, although thyroid-stimulating hormone levels became elevated after total thyroidectomy.


Conclusion: Although thyroid hormone is thought to play a role in the physiology of hearing in humans, no deleterious effects on hearing can be identified up to 6 weeks after thyroxin depletion

Fuente: The Laryngoscope, Volume 109, Issue 3, pages 343–350, March 1999
Mra, Z. and Wax, M. K. (1999), Effects of acute thyroxin depletion on hearing in humans. The Laryngoscope, 109: 343–350. doi: 10.1097/00005537-199903000-00001