miércoles, 6 de abril de 2011

Developmental Plasticity Of Auditory Cortical Inhibitory Synapses

Developmental Plasticity Of Auditory Cortical Inhibitory Synapses
Dan H. Sanes1, 2, Corresponding Author Contact Information, E-mail The Corresponding Author and Vibhakar C. Kotak1
1 Center for Neural Science New York University, New York, NY 10003
2 Department of Biology, New York University, New York, NY 10003
Received 7 December 2010; 
revised 22 March 2011; 
accepted 28 March 2011. 
Available online 2 April 2011.


Functional inhibitory synapses form in auditory cortex well before the onset of normal hearing.
However, their properties change dramatically during normal development, and many of these maturational events are delayed by hearing loss.
Here, we review recent findings on the developmental plasticity of inhibitory synapse strength, kinetics, and GABAA receptor localization in auditory cortex.

Although hearing loss generally leads to a reduction of inhibitory strength, this depends on the type of presynaptic interneuron.

Furthermore, plasticity of inhibitory synapses also depends on the postsynaptic target.

Hearing loss leads reduced GABAA receptor localization to the membrane of excitatory, but not inhibitory neurons.

A reduction in normal activity in development can also affect the use-dependent plasticity of inhibitory synapses.

Even moderate hearing loss can disrupt inhibitory short- and long-term synaptic plasticity.

Thus, the cortex did not compensate for the loss of inhibition in the brainstem, but rather exacerbated the response to hearing loss by further reducing inhibitory drive.

Together, these results demonstrate that inhibitory synapses are exceptionally dynamic during development, and deafness-induced perturbation of inhibitory properties may have a profound impact on auditory processing.
Key words: development; deafness; inhibitory interneuron; short-term depression; long-term potentiation; auditory cortex


No hay comentarios:

Publicar un comentario