sábado, 26 de febrero de 2011

Acúfenos: Sección mecanismos, teoria de la epilepsia talamo-cortical.

Contributions of the Thalamocortical system towards sound-specific auditory plasticity
Xiuping Liua, Sidhesh Basavaraja, Ramya Krishnana and Jun YanCorresponding Author Contact Information, a, E-mail The Corresponding Author
a Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
Received 31 August 2010; 
revised 14 February 2011; 
accepted 16 February 2011. 
Available online 22 February 2011.

Abstract

The function of the auditory cortex is dynamic.
Although auditory cortical plasticity can be induced through various approaches such as learning, experience and sensory deprivation, a common property is the frequency-specificity; the change in neuronal receptive field or functional maps is highly specific to the frequency content of the acquired sound.

This unique property suggests that precise frequency information must be relayed to the auditory cortex.

It is well known that the auditory thalamocortical pathway is the only neural substrate that sends precise frequency information to the auditory cortex.

This review addresses the impact of the auditory thalamocortical system on cortical plasticity.

The frequency-specificity of auditory cortical plasticity and the tonotopic features of the auditory thalamocortical system are briefly presented.

A discussion of the decisive role of thalamocortical system follows.

After an exploration of a possible synaptic mechanism, a thalamocortical model is proposed to better interpret the neural mechanisms underlying frequency-specific plasticity of the auditory cortex.

Corresponding Author Contact InformationCorresponding author. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. Tel.: +403 220 5518; fax: +403 270 3145

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