Hiperacusia: Sección mecanismos fisopatologicos.

Brain activation in patients with idiopathic hyperacusis

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Juen-Haur Hwang MD^a, Pao-Hsuan Chou^b, Chang-Wei Wu PhD^c, Jyh-Horng Chen PhD^c and Tien-Chen Liu MD, PhD^{d, ,}

^aDepartment of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, and School of Medicine, Tzu Chi University, Hualien, Taiwan
^bDepartment of Otolaryngology, Taichung Veterans General Hospital, Taichung
^cInterdisciplinary MRI/MRS Laboratory, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
^dDepartment of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan

Received 21 July 2008. 

Available online 6 March 2009.

Abstract

The neural network associated with idiopathic hyperacusis is still not well known.

We studied the brain activation of 3 middle-aged patients with mild to moderate hyperacusis by functional magnetic resonance imaging while they were listening to white noise binaurally.

In addition to the temporal lobes, in all patients, sound elicited activation in the frontal lobes (superior, middle, or inferior frontal gyri) and occipital lobes (precuneus, cuneus, superior occipital gyrus, lingual gyrus, or fusiform gyrus).

The parahippocampus was activated in 2 of 3 patients.

Furthermore, the precentral and postcentral gyri, superior and inferior parietal lobules, thalamus, midbrain, claustrum, insula, posterior cingulated gyrus, and orbital and rectal gyrus were also activated in one patient.

The neural network associated with idiopathic hyperacusis might be associated with the frontal lobes and parahippocampus.

Corresponding author. Department of Otolaryngology, National Taiwan University Hospital, No 7, Chung-Shan S. Road, Taipei, Taiwan. Tel.: +886 2 23123456x5896; fax: +886 2 23410905.

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Fuente: American Journal of Otolaryngology
Volume 30, Issue 6, November-December 2009, Pages 432-434